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Study Overview

This clinical study, sponsored by Dong Peng and conducted at the First Affiliated Hospital of Chongqing Medical University and other locations in China, investigates the impact of environmental pollution on obesity. The study aims to explore how pollutants such as PM2.5, PM5, PM10, SO2, NOX, O3, and the greening index influence obesity levels and related health outcomes. Additionally, it seeks to identify potential mechanisms by which environmental pollution contributes to obesity.

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Study Design

• Type: Observational, retrospective cohort study.
• Population: Obese patients (BMI ≥ 30) aged 18 and older from regions with varying pollution levels.
• Sample Size: Estimated enrollment of 800 participants.
• Time Frame: Data collection spans from 2011 to 2024, with primary completion by October 30, 2024.

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Objectives

1. Primary Objective:

• Assess the relationship between environmental pollution and the incidence of obesity (time from overweight to obesity).

1. Secondary Objectives:

• Investigate the association between pollution levels and blood test characteristics (e.g., renal function, sex hormones, glucose tolerance, trace elements, liver function, and blood routine).
• Explore potential mechanisms by which pollution promotes obesity.

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Eligibility Criteria

• Inclusion:
• Age ≥ 18 years.
• BMI ≥ 30.
• No prior surgical treatment for obesity.
• Willingness to participate and provide informed consent.
• Complete clinical data.
• Exclusion:
• Severe systemic diseases (e.g., cardiorespiratory insufficiency).
• Incomplete clinical data.
• Investigator-deemed ineligibility.

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Study Locations

1. Chongqing, China: First Affiliated Hospital of Chongqing Medical University.
2. Kunming, Yunnan, China: Affiliated Hospital of Yunnan University.
3. Qujing, Yunnan, China: Second People’s Hospital of Qujing.

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Key Measures

• Primary Outcome: Incidence of obesity over time.
• Secondary Outcomes: Blood test results and potential mechanisms linking pollution to obesity.

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Implications

This study could provide critical insights into how environmental pollution contributes to obesity and related health conditions. By identifying specific pollutants and mechanisms, the findings may inform public health policies and interventions to reduce pollution-related health risks.

Sponsored

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Conclusion

The NCT06670703 study represents a significant effort to understand the complex relationship between environmental pollution and obesity. Its findings could pave the way for targeted strategies to mitigate the impact of pollution on public health, particularly in regions with high pollution levels.

Prepared by:FR STAFF

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This summary is based on the study details available on ClinicalTrials.gov. For more information, refer to the original study page.